Talaromycosis is an invasive mycosis endemic in tropical and subtropical Asia and is
caused by the pathogenic fungus Talaromyces marneffei. Approximately 17,300 cases of T …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Much of medical research relies on animal models to deepen knowledge of the causes of
animal and human diseases, as well as to enable the development of innovative therapies …

Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Invasive fungal infections cause significant morbidity and mortality in part due to a limited
antifungal drug arsenal. One therapeutic challenge faced by clinicians is the significant host …

It has now become accepted that the immune system and neuroendocrine system form an
integrated part of our physiology. Immunological defense mechanisms act in concert with …

Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

The specific roles of the two major innate immune cell types–neutrophils and macrophages–
in response to infection and sterile inflammation are areas of great interest. The larval …