Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Cancer Letters, 2021 - Elsevier
The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

The role of resveratrol in cancer therapy

JH Ko, G Sethi, JY Um, MK Shanmugam… - International journal of …, 2017 - mdpi.com
Natural product compounds have recently attracted significant attention from the scientific
community for their potent effects against inflammation-driven diseases, including cancer. A …

Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression

FL Sarmiento-Salinas, A Perez-Gonzalez… - Life Sciences, 2021 - Elsevier
Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

An update on pharmacological potential of boswellic acids against chronic diseases

NK Roy, D Parama, K Banik, D Bordoloi… - International journal of …, 2019 - mdpi.com
Natural compounds, in recent years, have attracted significant attention for their use in the
prevention and treatment of diverse chronic diseases as they are devoid of major toxicities …

Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy

NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
Abstract The coronavirus disease (COVID-19) has once again reminded us of the
significance of host immune response and consequential havocs of the immune …

Pro-apoptotic and anti-cancer properties of diosgenin: a comprehensive and critical review

G Sethi, MK Shanmugam, S Warrier, M Merarchi… - Nutrients, 2018 - mdpi.com
Novel and alternative options are being adopted to combat the initiation and progression of
human cancers. One of the approaches is the use of molecules isolated from traditional …