Notch signaling augments BMP9-induced bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells (MSCs)

J Liao, Q Wei, Y Zou, J Fan, D Song, J Cui… - Cellular Physiology and …, 2017 - karger.com
Abstract Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that
can differentiate into several lineages including bone. Successful bone formation requires …

A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration

Y Wang, S Chen, Z Yan, M Pei - Cell & Bioscience, 2019 - Springer
Cellular senescence is a major hurdle for primary cell-based tissue engineering and
regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes …

[HTML][HTML] Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs)

H Zhang, J Wang, F Deng, E Huang, Z Yan, Z Wang… - Biomaterials, 2015 - Elsevier
Dental pulp/dentin regeneration using dental stem cells combined with odontogenic factors
may offer great promise to treat and/or prevent premature tooth loss. Here, we investigate if …

[HTML][HTML] lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling

J Liao, X Yu, X Hu, J Fan, J Wang, Z Zhang, C Zhao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can undergo self-
renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a …

[HTML][HTML] Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering

J Zhong, H Wang, K Yang, H Wang, C Duan, N Ni… - Bioactive Materials, 2022 - Elsevier
Skin injury is repaired through a multi-phase wound healing process of tissue granulation
and re-epithelialization. Any failure in the healing process may lead to chronic non-healing …

TqPCR: a touchdown qPCR assay with significantly improved detection sensitivity and amplification efficiency of SYBR green qPCR

Q Zhang, J Wang, F Deng, Z Yan, Y Xia, Z Wang, J Ye… - PloS one, 2015 - journals.plos.org
The advent of fluorescence-based quantitative real-time PCR (qPCR) has revolutionized the
quantification of gene expression analysis in many fields, including life sciences, agriculture …

[HTML][HTML] Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic …

J Fan, Q Wei, J Liao, Y Zou, D Song, D Xiong, C Ma… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The liver provides vital metabolic, exocrine and endocrine functions in the body as such
pathological conditions of the liver lead to high morbidity and mortality. The liver is highly …

Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells …

L Zhang, Q Luo, Y Shu, Z Zeng, B Huang, Y Feng… - Genes & diseases, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are ubiquitously-existing multipotent progenitors that can
self-renew and differentiate into multiple lineages including osteocytes, chondrocytes …

Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway

X Wang, X Wu, Z Zhang, C Ma, T Wu, S Tang… - Scientific Reports, 2018 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with<
5% five-year survival rate due to late diagnosis, limited treatment options and …

Thermoresponsive citrate-based graphene oxide scaffold enhances bone regeneration from BMP9-stimulated adipose-derived mesenchymal stem cells

C Zhao, Z Zeng, NT Qazvini, X Yu… - ACS biomaterials …, 2018 - ACS Publications
Effective bone tissue engineering is important to overcome the unmet clinical challenges as
more than 1.6 million bone grafts are done annually in the United States. Successful bone …