The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Memory is central to many aspects of behaviour, but in spite of a long interest in its neural
basis, empirical evidence of the nature of the hypothetical pathway that is left in the …

Microglia-mediated neuroinflammation is implicated in multiple neurodegenerative
disorders, including Parkinson's disease (PD). Hence, the modulatioein of sustained …

In the present era, investigators seek to find therapeutic interventions that are multifaceted in
their mode of action. Such targets provide the most advantageous routes for addressing the …

A variety of experimental studies demonstrated that neurotransmitters are an important factor
for the development of the central nervous system, affecting neurodevelopmental events like …

We describe an analytical methodology to obtain high sensitivity and better resolution
through the study of fluorometric excitation (λ ex) and emission (λ em) spectrum wavelengths …

The aim of this study was to indentify the involvement of leptin receptors (LepR) in astrocytes
in hippocampal synaptic transmission and plasticity and metabolism. To this end we used a …

Intermittent and excessive ethanol consumption over very short periods of time, known as
binge drinking, is common in the adolescence, considered a vulnerable period to the effects …

A reduction in taurine content accompanies the ageing process in many tissues. In fact, the
decline of brain taurine levels has been associated with cognitive deficits whereas chronic …

Aging-related biochemical changes in nerve cells lead to dysfunctional synapses and
disrupted neuronal circuits, ultimately affecting vital processes such as brain plasticity …