Role of haeme oxygenase‐1 in resolution of oxidative stress‐related pathologies: focus on cardiovascular, lung, neurological and kidney disorders

DD Haines, I Lekli, P Teissier, I Bak… - Acta …, 2012 - Wiley Online Library
The present review examines the role of the cytoprotective enzyme haeme oxygenase‐1
(HO‐1) in adaptive responses to inflammatory disease and explores strategies for its clinical …

[HTML][HTML] 5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction

M Fujino, Y Nishio, H Ito, T Tanaka, XK Li - International …, 2016 - Elsevier
Aminolevulinic acid (5-ALA) is a naturally occurring amino acid and precursor of heme and
protoporphyrin IX (PpIX). Exogenously administrated 5-ALA increases the accumulation of …

FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy

CD Touchberry, TM Green… - American Journal …, 2013 - journals.physiology.org
Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that
regulates phosphate and vitamin D metabolism. Recent observational studies in humans …

Isothiocyanates protect against oxidized LDL‐induced endothelial dysfunction by upregulating Nrf2‐dependent antioxidation and suppressing NFκB activation

CS Huang, AH Lin, CT Liu, CW Tsai… - Molecular nutrition & …, 2013 - Wiley Online Library
Scope Oxidative stress plays a pivotal role in the pathophysiology of cardiovascular
diseases. Oxidized low‐density lipoprotein (oxLDL) is a key contributor to atherogenesis …

Heme oxygenase-1 modulates human respiratory syncytial virus replication and lung pathogenesis during infection

JA Espinoza, MA León, PF Céspedes… - The Journal of …, 2017 - journals.aai.org
Human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory
tract infections in children. The development of novel prophylactic and therapeutic antiviral …

Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway

M Li, X Liu, Y He, Q Zheng, M Wang, Y Wu… - European Journal of …, 2017 - Elsevier
Abstract Angiotensin II (Ang II), as a crucial factor of endothelial dysfunction, participates in
endothelial oxidative damage and inflammation, which is present in all cardiovascular …

Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

JB Rose, Z Naydenova, A Bang… - American Journal …, 2010 - journals.physiology.org
To better understand the role of equilibrative nucleoside transporters (ENT) in purine
nucleoside-dependent physiology of the cardiovascular system, we investigated whether the …

Expression and function of heme oxygenase-1 in human gastric cancer

Y Yin, Q Liu, B Wang, G Chen, L Xu… - … Biology and Medicine, 2012 - journals.sagepub.com
Heme oxygenase-1 (HO-1) potently influences tumor growth and metastasis. To date, no
study has been performed on HO-1 expression pattern and its clinicopathological …

Role of Nrf2 signaling in the regulation of vascular BK channel β1 subunit expression and BK channel function in high-fat diet–induced diabetic mice

T Lu, X Sun, Y Li, Q Chai, XL Wang, HC Lee - Diabetes, 2017 - Am Diabetes Assoc
The large conductance Ca2+-activated K+ (BK) channel β1-subunit (BK-β1) is a key
modulator of BK channel electrophysiology and the downregulation of BK-β1 protein …

Induction of heme oxygenase 1 and inhibition of tumor necrosis factor α-induced intercellular adhesion molecule expression by andrographolide in EA. hy926 cells

AL Yu, CY Lu, TS Wang, CW Tsai, KL Liu… - Journal of agricultural …, 2010 - ACS Publications
Andrographolide is the most abundant diterpene lactone in Andrographis paniculata, which
is widely used as a traditional medicine in Southeast Asia. Heme oxygenase 1 (HO-1) is an …