The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …

Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

In general, iron represents a double-edged sword in metabolism in most tissues, especially
in the brain. Although the high metabolic demands of brain cells require iron as a redox …

Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most
common cause of dementia and has no treatment. It is characterized by two pathological …

Alzheimer's disease (AD) is a very disabling disease. Pathologically, it is characterized by
the presence of amyloid plaques and neurofibrillary tangles in the brain that results in …

The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported.
However, their formation in cells and their cellular roles were not resolved. Here, by taking a …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens elderly
health. Schisandrin (SCH) and nootkatone (NKT) are two core components derived from …