Adverse reactions to snake antivenom, and their prevention and treatment

HA de Silva, NM Ryan… - British journal of clinical …, 2016 - Wiley Online Library
Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse
reactions to snake antivenom that is available are common in many parts of the world where …

Snakebite envenoming from a global perspective: Towards an integrated approach

JM Gutiérrez, D Williams, HW Fan, DA Warrell - Toxicon, 2010 - Elsevier
Snakebite envenoming is a neglected public health challenge of compelling importance in
many regions of the world, particularly sub-Saharan Africa, Asia, Latin America and Papua …

[图书][B] Hayes' principles and methods of toxicology

AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Confronting the neglected problem of snake bite envenoming: the need for a global partnership

JM Gutiérrez, RDG Theakston, DA Warrell - PLoS medicine, 2006 - journals.plos.org
Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global
Partnership | PLOS Medicine Skip to main content Advertisement PLOS Medicine Browse …

Epidemiological, clinical and therapeutic aspects of Bothrops asper bites

R Otero-Patino - Toxicon, 2009 - Elsevier
Bothrops asper inflicts the majority of snakebites in Central America and in the northern
regions of South America, mostly affecting young agricultural workers in rural settings. This …

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

JM Gutiérrez, B Lomonte, G León, A Alape-Giron… - Journal of …, 2009 - Elsevier
Snakebite envenoming represents a neglected tropical disease that has a heavy public
health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at …

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms

G León, M Herrera, Á Segura, M Villalta, M Vargas… - Toxicon, 2013 - Elsevier
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments,
purified from the plasma of animals immunized with snake venoms. Their therapeutic …

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

RA Harrison, GO Oluoch, S Ainsworth… - PLoS neglected …, 2017 - journals.plos.org
Background Antivenom is the treatment of choice for snakebite, which annually kills an
estimated 32,000 people in sub-Saharan Africa and leaves approximately 100,000 survivors …

Antivenoms for the treatment of snakebite envenomings: the road ahead

JM Gutiérrez, G León, T Burnouf - Biologicals, 2011 - Elsevier
The parenteral administration of antivenoms is the cornerstone of snakebite envenoming
therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are …

Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind …

HA de Silva, A Pathmeswaran, CD Ranasinha… - PLoS …, 2011 - journals.plos.org
Background Envenoming from snakebites is most effectively treated by antivenom. However,
the antivenom available in South Asian countries commonly causes acute allergic reactions …