Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal
cells (MSC) are complex and highly regulated processes. Over the years, several studies …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

During the past decade, there has been a rapidly increased appreciation of the role of
translation as a key regulatory node in gene expression. Thereby, the development of …

Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian
oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans …

The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and
other lineages are known to be controlled by various extrinsic and intrinsic signals. The …

The importance of mesenchymal stem cells (MSC) for bone regeneration is growing. Among
MSC the bone marrow-derived stem cells (BMSC) are considered the gold standard in …

Genome-wide studies of transcripts expression help in systematic monitoring of genes and
allow targeting of candidate genes for future research. In contrast to relatively stable …

The adipogenic process is characterized by the expression of adipocyte differentiation
markers that lead to changes in cell metabolism and to the accumulation of lipid droplets …

The understanding of metabolism during cell proliferation and commitment provides a
greater insight into the basic biology of cells, allowing future applications. Here we …