Harnessing human genetics and stem cells for precision cardiovascular medicine
Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …
pharmaceutical research by providing tissue-specific human cells that retain patients' …
The multifaceted role of mitochondria in cardiac function: insights and approaches
S Ravindran, CD Rau - Cell Communication and Signaling, 2024 - Springer
Cardiovascular disease (CVD) remains a global economic burden even in the 21st century
with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors …
with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors …
Deciphering KDM8 dysregulation and CpG methylation in hepatocellular carcinoma using multi-omics and machine learning
Aim: This study investigates the altered expression and CpG methylation patterns of histone
demethylase KDM8 in hepatocellular carcinoma (HCC), aiming to uncover insights and …
demethylase KDM8 in hepatocellular carcinoma (HCC), aiming to uncover insights and …
Leveraging metabolism for better outcomes in heart failure
YH Ng, YC Koay, FZ Marques, DM Kaye… - Cardiovascular …, 2024 - academic.oup.com
Whilst metabolic inflexibility and substrate constraint have been observed in heart failure for
many years, their exact causal role remains controversial. In parallel, many of our …
many years, their exact causal role remains controversial. In parallel, many of our …
Epigenetic regulation of heart failure
M Deogharia, P Gurha - Current Opinion in Cardiology, 2024 - journals.lww.com
Epigenetic modifications provide a mechanism for responding to stress and environmental
variation, enabling reactions to both external and internal stimuli, and their dysregulation …
variation, enabling reactions to both external and internal stimuli, and their dysregulation …