Holistic integration of omics tools for precision nutrition in health and disease
The combination of multiple omics approaches has emerged as an innovative holistic scope
to provide a more comprehensive view of the molecular and physiological events underlying …
to provide a more comprehensive view of the molecular and physiological events underlying …
Towards building a quantitative proteomics toolbox in precision medicine: a mini-review
Precision medicine as a framework for disease diagnosis, treatment, and prevention at the
molecular level has entered clinical practice. From the start, genetics has been an …
molecular level has entered clinical practice. From the start, genetics has been an …
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
Abstract The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between
the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …
Mapping biological influences on the human plasma proteome beyond the genome
J Carrasco-Zanini, E Wheeler, B Uluvar, N Kerrison… - Nature …, 2024 - nature.com
Broad-capture proteomic platforms now enable simultaneous assessment of thousands of
plasma proteins, but most of these are not actively secreted and their origins are largely …
plasma proteins, but most of these are not actively secreted and their origins are largely …
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the
mechanisms underlying this relationship are not fully understood. As obesity influences the …
mechanisms underlying this relationship are not fully understood. As obesity influences the …
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection …
A Venkateshvaran, UL Faxen, C Hage… - European journal of …, 2022 - Wiley Online Library
Aim Epicardial adipose tissue (EAT) may play a role in the pathophysiology of heart failure
with preserved ejection fraction (HFpEF). We investigated associations of EAT with …
with preserved ejection fraction (HFpEF). We investigated associations of EAT with …
An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome
O Delannoy-Bruno, C Desai… - Proceedings of the …, 2022 - National Acad Sciences
Increases in snack consumption associated with Westernized lifestyles provide an
opportunity to introduce nutritious foods into poor diets. We describe two 10-wk-long open …
opportunity to introduce nutritious foods into poor diets. We describe two 10-wk-long open …
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population
Abstract Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression,
treatment, and complications. A data driven cluster analysis in European individuals with …
treatment, and complications. A data driven cluster analysis in European individuals with …
Canonical correlation analysis for multi-omics: Application to cross-cohort analysis
Integrative approaches that simultaneously model multi-omics data have gained increasing
popularity because they provide holistic system biology views of multiple or all components …
popularity because they provide holistic system biology views of multiple or all components …
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations
Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide
genetics-based personalized medicine. However, it is not clear how well PGS translate …
genetics-based personalized medicine. However, it is not clear how well PGS translate …