Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Uterine fibroids affect a wide cross-section of the population, with prevalence, symptom
severity, and overall disease burden generally higher among black women, likely due to …

BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

Uterine leiomyomas are benign smooth-muscle tumors of extremely low malignant potential.
Early work utilizing classical cytogenetics revealed that a subset of uterine leiomyomas …

OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …

Background It is well established that tumors are dependent on angiogenesis for their
growth and survival. Although uterine fibroids are known to be benign tumors with reduced …

Objective To provide a detailed summary of current scientific knowledge on uterine fibroids
(leiomyomas) in vitro and in in vivo animal models, as well as to postulate the potential role …

STUDY QUESTION What are the cellular composition and single-cell transcriptomic
differences between myometrium and leiomyomas as defined by single-cell RNA …

Mediator is a conserved multi-subunit signal processor through which regulatory
informatiosn conveyed by gene-specific transcription factors is transduced to RNA …