Neuromodulatory pathways in learning and memory: Lessons from invertebrates

S Van Damme, N De Fruyt, J Watteyne… - Journal of …, 2021 - Wiley Online Library
In an ever‐changing environment, animals have to continuously adapt their behaviour. The
ability to learn from experience is crucial for animals to increase their chances of survival. It …

Assessing single-cell transcriptomic variability through density-preserving data visualization

A Narayan, B Berger, H Cho - Nature biotechnology, 2021 - nature.com
Nonlinear data visualization methods, such as t-distributed stochastic neighbor embedding
(t-SNE) and uniform manifold approximation and projection (UMAP), summarize the …

Emerging roles of RNA-binding proteins in neurodevelopment

AS Parra, CA Johnston - Journal of Developmental Biology, 2022 - mdpi.com
Diverse cell types in the central nervous system (CNS) are generated by a relatively small
pool of neural stem cells during early development. Spatial and temporal regulation of stem …

Evolutionary conserved role of neural cell adhesion molecule-1 in memory

V Vukojevic, P Mastrandreas, A Arnold, F Peter… - Translational …, 2020 - nature.com
The neural cell adhesion molecule 1 (NCAM-1) has been implicated in several brain-related
biological processes, including neuronal migration, axonal branching, fasciculation, and …

Density-preserving data visualization unveils dynamic patterns of single-cell transcriptomic variability

A Narayan, B Berger, H Cho - bioRxiv, 2020 - biorxiv.org
Nonlinear data-visualization methods, such as t-SNE and UMAP, have become staple tools
for summarizing the complex transcriptomic landscape of single cells in 2D or 3D. However …

Muscleblind-1 interacts with tubulin mRNAs to regulate the microtubule cytoskeleton in C. elegans mechanosensory neurons

D Puri, S Sharma, S Samaddar, S Ravivarma… - PLoS …, 2023 - journals.plos.org
Regulation of the microtubule cytoskeleton is crucial for the development and maintenance
of neuronal architecture, and recent studies have highlighted the significance of regulated …

Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network

BG Fenyves, GS Szilágyi, Z Vassy, C Sőti… - PLoS Computational …, 2020 - journals.plos.org
Graph theoretical analyses of nervous systems usually omit the aspect of connection
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …

Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans

K Peymen, J Watteyne, C Borghgraef, E Van Sinay… - PLoS …, 2019 - journals.plos.org
Aversive learning and memories are crucial for animals to avoid previously encountered
stressful stimuli and thereby increase their chance of survival. Neuropeptides are essential …

Behavioral screening reveals a conserved residue in Y-Box RNA-binding protein required for associative learning and memory in C. elegans

AN Hayden, KL Brandel, EW Pietryk, PR Merlau… - PLoS …, 2024 - journals.plos.org
RNA-binding proteins (RBPs) regulate translation and plasticity which are required for
memory. RBP dysfunction has been linked to a range of neurological disorders where …

CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression

JS Park, H Oh, DY Kim, YJ Cheon, YJ Park… - PLoS …, 2021 - journals.plos.org
Animals can adapt to dynamic environmental conditions by modulating their developmental
programs. Understanding the genetic architecture and molecular mechanisms underlying …