[HTML][HTML] No easy way out for EZH2: its pleiotropic, noncanonical effects on gene regulation and cellular function
Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes
including organ development and homeostasis, epigenomic and transcriptomic regulation …
including organ development and homeostasis, epigenomic and transcriptomic regulation …
EZH2 function in immune cell development
The polycomb repressive complex 2 (PRC2) consists of three core components EZH2,
SUZ12 and EED. EZH2 catalyzes the methylation of lysine 27 of histone H3, a modification …
SUZ12 and EED. EZH2 catalyzes the methylation of lysine 27 of histone H3, a modification …
[HTML][HTML] EZH2 inhibition and cisplatin as a combination anticancer therapy: an overview of preclinical studies
Simple Summary Cisplatin is a chemotherapy drug widely used in the treatment of different
cancer types. However, cisplatin displays a high range of toxicity and its use usually leads to …
cancer types. However, cisplatin displays a high range of toxicity and its use usually leads to …
[HTML][HTML] Non-canonical functions of EZH2 in cancer
SM Zimmerman, PN Lin, GP Souroullas - Frontiers in Oncology, 2023 - frontiersin.org
Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Most
mechanistic studies focus on their canonical functions, while therapeutic approaches target …
mechanistic studies focus on their canonical functions, while therapeutic approaches target …
Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias
M Poplineau, N Platet, A Mazuel… - Blood, The Journal …, 2022 - ashpublications.org
Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …
Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2
W Huang, G Su, X Huang, A Zou, J Wu, Y Yang, Y Zhu… - Cell Cycle, 2019 - Taylor & Francis
Prostate cancer-associated ncRNA transcript 6 (PCAT6) is a long intergenic noncoding RNA
that is involved in the progression of prostate and lung cancer, acting as a potential …
that is involved in the progression of prostate and lung cancer, acting as a potential …
Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Acquired chromosomal DNA copy gains are a feature of many tumors; however, the
mechanisms that underpin oncogene amplification are poorly understood. Recent studies …
mechanisms that underpin oncogene amplification are poorly understood. Recent studies …
Long noncoding RNA PART1 restrains aggressive gastric cancer through the epigenetic silencing of PDGFB via the PLZF-mediated recruitment of EZH2
H Han, S Wang, J Meng, G Lyu, G Ding, Y Hu, L Wang… - Oncogene, 2020 - nature.com
Current reports refer to the role of long noncoding RNA (lncRNA) prostate androgen-
regulated transcript 1 (PART1) as a tumor suppressor in some types of cancer but as an …
regulated transcript 1 (PART1) as a tumor suppressor in some types of cancer but as an …
Transactivation of herpes simplex virus 1 (HSV-1) infected cell protein 4 enhancer by glucocorticoid receptor and stress-induced transcription factors requires …
JB Ostler, P Thunuguntla, BY Hendrickson… - Journal of …, 2021 - Am Soc Microbiol
Following acute infection, herpes simplex virus 1 (HSV-1) lytic cycle viral gene expression is
silenced; consequently, lifelong latency in neurons is established. Certain external stimuli …
silenced; consequently, lifelong latency in neurons is established. Certain external stimuli …
Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries
M Liu, K Hummitzsch, MD Hartanti… - Biology of …, 2020 - academic.oup.com
Polycystic ovary syndrome (PCOS) appears to have a genetic predisposition and a fetal
origin. We compared the expression levels of 25 PCOS candidate genes from adult control …
origin. We compared the expression levels of 25 PCOS candidate genes from adult control …