Sulfur (VI) fluoride exchange (SuFEx): another good reaction for click chemistry
Aryl sulfonyl chlorides (eg Ts‐Cl) are beloved of organic chemists as the most commonly
used SVI electrophiles, and the parent sulfuryl chloride, O2SVICl2, has also been relied on …
used SVI electrophiles, and the parent sulfuryl chloride, O2SVICl2, has also been relied on …
Click chemistry for drug development and diverse chemical–biology applications
P Thirumurugan, D Matosiuk, K Jozwiak - Chemical reviews, 2013 - ACS Publications
Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …
molecules, has gradually undertaken the more challenging task of biology-oriented …
Combinatorial chemistry in drug discovery
Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …
Graphene-based wireless bacteria detection on tooth enamel
Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring
and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due …
and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due …
Intelligent biomaterialomics: molecular design, manufacturing, and biomedical applications
Y Yi, HW An, H Wang - Advanced Materials, 2024 - Wiley Online Library
Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …
and has changed the paradigm for the research and development of new functional …
Single-cell systems biology by super-resolution imaging and combinatorial labeling
Fluorescence microscopy is a powerful quantitative tool for exploring regulatory networks in
single cells. However, the number of molecular species that can be measured …
single cells. However, the number of molecular species that can be measured …
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …
In situ click chemistry: probing the binding landscapes of biological molecules
SK Mamidyala, MG Finn - Chemical Society Reviews, 2010 - pubs.rsc.org
Combinatorial approaches to the discovery of new functional molecules are well established
among chemists and biologists, inspired in large measure by the modular composition of …
among chemists and biologists, inspired in large measure by the modular composition of …
Aptamers and the next generation of diagnostic reagents
V Thiviyanathan, DG Gorenstein - PROTEOMICS–Clinical …, 2012 - Wiley Online Library
Antibodies have been extensively used as capture and detection reagents in diagnostic
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
High-Q Optical Sensors for Chemical and Biological Analysis
MS Luchansky, RC Bailey - Analytical chemistry, 2012 - ACS Publications
Optical sensors represent a vitally important class of analytical tools that have been used to
provide chemical information ranging from analyte concentration and binding kinetics to …
provide chemical information ranging from analyte concentration and binding kinetics to …