The radioresistant and survival mechanisms of Deinococcus radiodurans

F Liu, N Li, Y Zhang - Radiation Medicine and Protection, 2023 - mednexus.org
Deinococcus radiodurans (D. radiodurans) is distinguished by the most radioresistant
organism ever known, and can tolerate extreme environments such as ionizing radiation …

Structure and assembly of the S-layer in C. difficile

P Lanzoni-Mangutchi, O Banerji, J Wilson… - Nature …, 2022 - nature.com
Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers
the cell surface and plays crucial roles in cell physiology. Here, we report the crystal …

An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition

J Witwinowski, A Sartori-Rupp, N Taib, N Pende… - Nature …, 2022 - nature.com
Recent data support the hypothesis that Gram-positive bacteria (monoderms) arose from
Gram-negative ones (diderms) through loss of the outer membrane (OM), but how this …

A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria

A von Kügelgen, S van Dorst, V Alva… - Proceedings of the …, 2022 - National Acad Sciences
Deinococcus radiodurans is a phylogenetically deep-branching extremophilic bacterium that
is remarkably tolerant to numerous environmental stresses, including large doses of …

[HTML][HTML] Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans

DL Sexton, S Burgold, A Schertel, EI Tocheva - Current Research in …, 2022 - Elsevier
Studying bacterial cell envelope architecture with electron microscopy is challenging due to
the poor preservation of microbial ultrastructure with traditional methods. Here, we …

The structured organization of Deinococcus radiodurans' cell envelope

D Farci, P Haniewicz, D Piano - Proceedings of the …, 2022 - National Acad Sciences
Surface layers (S-layers) are highly ordered coats of proteins localized on the cell surface of
many bacterial species. In these structures, one or more proteins form elementary units that …

The cryo-EM structure of the S-layer deinoxanthin-binding complex of Deinococcus radiodurans informs properties of its environmental interactions

D Farci, P Haniewicz, D de Sanctis, L Iesu… - Journal of Biological …, 2022 - ASBMB
The radiation-resistant bacterium Deinococcus radiodurans is known as the world's toughest
bacterium. The S-layer of D. radiodurans, consisting of several proteins on the surface of the …

Structural characterization and functional insights into the type II secretion system of the poly-extremophile Deinococcus radiodurans

D Farci, S Milenkovic, L Iesu, M Tanas… - Journal of Biological …, 2024 - ASBMB
The extremophile bacterium D. radiodurans boasts a distinctive cell envelope characterized
by the regular arrangement of three protein complexes. Among these, the Type II Secretion …

[HTML][HTML] Structural analysis of the architecture and in situ localization of the main S-layer complex in Deinococcus radiodurans

D Farci, S Kereïche, S Pangeni, P Haniewicz… - Structure, 2021 - cell.com
Bacterial surface layers are paracrystalline assemblies of proteins that provide the first line
of defense against environmental shocks. Here, we report the 3D structure, in situ …

The SDBC is active in quenching oxidative conditions and bridges the cell envelope layers in Deinococcus radiodurans

D Farci, AT Graça, L Iesu, D de Sanctis… - Journal of Biological …, 2023 - ASBMB
Deinococcus radiodurans is known for its remarkable ability to withstand harsh stressful
conditions. The outermost layer of its cell envelope is a proteinaceous coat, the S-layer …