Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Rationale: Ca2+ homeostasis—a critical determinant of cardiac contractile function—is
critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Hydrogel materials have great application value in biomedical engineering. Among them,
photocrosslinked hydrogels have attracted much attention due to their variety and simple …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates
cardiac gene expression. Here we show that the levels of an N-terminal proteolytically …

Background Right ventricular (RV) function is the most important prognostic factor for
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

Background—Stromal interaction molecule 1 (STIM1) is a dynamic calcium signal
transducer implicated in hypertrophic growth of cardiomyocytes. STIM1 is thought to act as …