NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
N Đukić, Ø Strømland, JD Elsborg, D Munnur, K Zhu… - Science …, 2023 - science.org
PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …
transcription, and DNA replication stress management. However, little is known about the …
Poly (ADP-ribosyl) ation by PARP1: reaction mechanism and regulatory proteins
EE Alemasova, OI Lavrik - Nucleic acids research, 2019 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is posttranslational modification of proteins by
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
Serine is the major residue for ADP-ribosylation upon DNA damage
Poly (ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-
ribosylation (ADPr), a reversible modification of proteins that regulates many different …
ribosylation (ADPr), a reversible modification of proteins that regulates many different …
(ADP-ribosyl) hydrolases: structure, function, and biology
ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …
Location, location, location: compartmentalization of NAD+ synthesis and functions in mammalian cells
XA Cambronne, WL Kraus - Trends in biochemical sciences, 2020 - cell.com
The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …
[HTML][HTML] ADP-ribosylation of DNA and RNA
ADP-ribosylation is a chemical modification of macromolecules found across all domains of
life and known to regulate a variety of cellular processes. Notably, it has a well-established …
life and known to regulate a variety of cellular processes. Notably, it has a well-established …
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation
J O'Sullivan, M Tedim Ferreira, JP Gagné… - Nature …, 2019 - nature.com
Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …