GRP78 targeting: Hitting two birds with a stone
AA Elfiky, AM Baghdady, SA Ali, MI Ahmed - Life sciences, 2020 - Elsevier
Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective
AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …
[HTML][HTML] Cerebral glucose metabolism and potential effects on endoplasmic reticulum stress in stroke
S Guo, A Wehbe, S Syed, M Wills, L Guan, S Lv… - Aging and …, 2023 - ncbi.nlm.nih.gov
Ischemic stroke is an extremely common pathology with strikingly high morbidity and
mortality rates. The endoplasmic reticulum (ER) is the primary organelle responsible for …
mortality rates. The endoplasmic reticulum (ER) is the primary organelle responsible for …
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN
K Zhang, C Yang, X Zhou, J Liang, J Guo, M Li… - Cellular and Molecular …, 2023 - Springer
Hepatic glucose and lipid metabolism disorders promote the development and progression
of type 2 diabetes mellitus (T2DM), yet the underlying mechanisms are not fully understood …
of type 2 diabetes mellitus (T2DM), yet the underlying mechanisms are not fully understood …
Recognition of gluconeogenic enzymes; Icl1, Fbp1, and Mdh2 by Gid4 ligase: A molecular docking study
AA Elfiky, AM Ismail… - Journal of Molecular …, 2020 - Wiley Online Library
The pro/N‐degron pathway is an evolved protein degradation pathway through the ubiquitin‐
proteasome system. It is a vital pathway to attain protein homeostasis inside the liver cells …
proteasome system. It is a vital pathway to attain protein homeostasis inside the liver cells …