White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study
Several prominent theories of schizophrenia suggest that structural white matter pathologies
may follow a developmental, maturational, and/or degenerative process. However, a lack of …
may follow a developmental, maturational, and/or degenerative process. However, a lack of …
Functional network connectivity impairments and core cognitive deficits in schizophrenia
BM Adhikari, LE Hong, H Sampath… - Human brain …, 2019 - Wiley Online Library
Cognitive deficits contribute to functional disability in patients with schizophrenia and may
be related to altered functional networks that serve cognition. We evaluated the integrity of …
be related to altered functional networks that serve cognition. We evaluated the integrity of …
Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings
Juvenile myoclonic epilepsy is the most common genetic generalized epilepsy syndrome,
characterized by a complex polygenetic aetiology. Structural and functional MRI studies …
characterized by a complex polygenetic aetiology. Structural and functional MRI studies …
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways
Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia
TM Gilbert, NR Zürcher, CJ Wu… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits.
Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the …
Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the …
Baseline cortical thickness reductions in clinical high risk for psychosis: brain regions associated with conversion to psychosis versus non-conversion as assessed at …
Objective To assess cortical thickness (CT) and surface area (SA) of frontal, temporal, and
parietal brain regions in a large clinical high risk for psychosis (CHR) sample, and to identify …
parietal brain regions in a large clinical high risk for psychosis (CHR) sample, and to identify …
Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study
JH Thygesen, A Presman, J Harju-Seppänen… - Molecular …, 2021 - nature.com
The burden of large and rare copy number genetic variants (CNVs) as well as certain
specific CNVs increase the risk of developing schizophrenia. Several cognitive measures …
specific CNVs increase the risk of developing schizophrenia. Several cognitive measures …
Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy
Objective Juvenile myoclonic epilepsy (JME) is the most common genetic generalized
epilepsy syndrome. Myoclonus may relate to motor system hyperexcitability and can be …
epilepsy syndrome. Myoclonus may relate to motor system hyperexcitability and can be …
Race modifies default mode connectivity in Alzheimer's disease
Abstract Background Older African Americans are more likely to develop Alzheimer's
disease (AD) than older Caucasians, and this difference cannot be readily explained by …
disease (AD) than older Caucasians, and this difference cannot be readily explained by …
Cognitive genomics: recent advances and current challenges
Abstract Purpose of Review We review recent progress in uncovering the complex genetic
architecture of cognition, arising primarily from genome-wide association studies (GWAS) …
architecture of cognition, arising primarily from genome-wide association studies (GWAS) …