Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
[HTML][HTML] Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges
LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …
human neonates, and is often associated with persistent motor, sensory, and cognitive …
Plasminogen: an enigmatic zymogen
CB Keragala, RL Medcalf - Blood, The Journal of the American …, 2021 - ashpublications.org
Plasminogen is an abundant plasma protein that exists in various zymogenic forms.
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …
tPA mobilizes immune cells that exacerbate hemorrhagic transformation in stroke
Rationale: Hemorrhagic complications represent a major limitation of intravenous
thrombolysis using tPA (tissue-type plasminogen activator) in patients with ischemic stroke …
thrombolysis using tPA (tissue-type plasminogen activator) in patients with ischemic stroke …
Glial and neuronal control of brain blood flow
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …
cells control blood flow is crucial for understanding how neural computation is powered, for …
[HTML][HTML] The science of stroke: mechanisms in search of treatments
MA Moskowitz, EH Lo, C Iadecola - Neuron, 2010 - cell.com
This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …
Mechanisms, challenges and opportunities in stroke
EH Lo, T Dalkara, MA Moskowitz - Nature reviews neuroscience, 2003 - nature.com
Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …
irreversibly damage brain cells after stroke. Much attention has focused on what makes …
Stroke and the immune system: from pathophysiology to new therapeutic strategies
R Macrez, C Ali, O Toutirais, B Le Mauff… - The Lancet …, 2011 - thelancet.com
Stroke is the second most common cause of death worldwide and a major cause of acquired
disability in adults. Despite tremendous progress in understanding the pathophysiology of …
disability in adults. Despite tremendous progress in understanding the pathophysiology of …
NMDA receptor subunits: diversity, development and disease
N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …
synapses in the central nervous system and display unique properties that depend on their …
[HTML][HTML] LRP: a multifunctional scavenger and signaling receptor
J Herz, DK Strickland - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …