The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

Hydrocephalus is one of the most common brain disorders and a life‐long incurable
condition. An empirical “one‐size‐fits‐all” approach of cerebrospinal fluid (CSF) shunting …

With-no-lysine kinases (WNKs) are a novel family of serine/threonine protein kinases
participating in ion homeostasis via the WNK-OSR1/SPAK-NKCC cascade. Recent studies …

The SLC9 gene family encodes Na+/H+ exchangers (NHEs), a group of membrane transport
proteins critically involved in the regulation of cytoplasmic and organellar pH, cell volume, as …

Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members,
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …

SPAK inhibitor ZT-1a was previously shown to be neuroprotective in murine ischemic stroke
models. In this study, we further examined the efficacy of four ZT-1a derivatives (ZT-1c,-1d …

The phosphorylation of histone H2A. X into γH2A. X is a crucial early event in the DNA
damage response, marking DNA damage sites and initiating repair processes. While ATM …

Despite the fact that there are several drugs available for the treatment of epilepsy,
pharmacoresistance remains a major challenge in seizure control. Therefore, a significant …

Background Nowadays little is known about the molecular profile of the occluding thrombus
of patients with ischemic stroke. Objectives To analyze the proteomic profile of thrombi in …

The purpose of this review is to highlight transformative advances that have been made in
the field of biomolecular condensates with special emphasis on condensate material …