We propose a generalization of the Weibull dissolution model, referred to as generalized
Weibull dissolution model, that seamlessly captures all three fractional dissolution rates …

An experimental investigation was carried out to study the mixing performance of a
laboratory-scale ResonantAcoustic® Mixer (LabRAM). The first part of the study summarizes …

Powder blend homogeneity is a critical attribute in formulation development of low dose and
potent active pharmaceutical ingredients (API) yet a complex process with multiple …

A method for predicting dissolution profiles of directly compressed tablets for a fixed
sustained release formulation manufactured in a continuous direct compaction (CDC) …

This study describes how the strain on formulation components affects dissolution and how
near infrared spectroscopy can be used to predict dissolution. Strain (exposure to shear …

The main objective of the present work was to study the effect of mixing order of Cab-O-Sil
(CS) and magnesium stearate (MgSt) and microlayers during mixing on blend and tablet …

Context: Tableting is a complex process due to the large number of process parameters that
can be varied. Knowledge and understanding of the influence of these parameters on the …

The impact of dry coating with hydrophobic or hydrophilic nano-silica at 25–100% surface
area coverage on dissolution of micronized poorly water-soluble drugs was investigated by …

Obtaining a desired content uniformity with satisfactory flowability is one of the main
challenges during blending process of the pre-mixture with lubricants. In this study, Discrete …

Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low
concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricant (Osorio …