In the Americas, areas with a high risk of malaria transmission are mainly located in the
Amazon Forest, which extends across nine countries. One keystone step to understanding …

Mosquitoes are responsible for the transmission of diseases with a serious impact on global
human health, such as malaria and dengue. All mosquito-transmitted pathogens complete …

Plasmodium ookinetes traverse midgut epithelial cells before they encounter the
complement system in the mosquito hemolymph. We identified a heme peroxidase (HPX2) …

The innate immune system of Anopheles gambiae mosquitoes limits Plasmodium infection
through multiple molecular mechanisms. For example, midgut invasion by the parasite …

Background Digestion of blood in the midgut of Aedes aegypti results in the release of pro-
oxidant molecules that can be toxic to the mosquito. We hypothesized that after a blood …

Insects are a powerful tool for discovering and then dissecting interesting new immunology.
Recent insect research has made productive forays into non-classical immune areas …

The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …

Hemocytes synthesize key components of the mosquito complement-like system, but their
role in the activation of antiplasmodial responses has not been established. The effect of …

The overexpression of activated, myristoylated Akt in the midgut of female transgenic
Anopheles stephensi results in resistance to infection with the human malaria parasite …

Adult females of Aedes aegypti are facultative blood sucking insects and vectors of Dengue
and yellow fever viruses. Insect dispersal plays a central role in disease transmission and …