Highlights•Protozoan parasites encode a diverse and dynamic 'epitranscriptome'.•mRNA
modifications mediate unique mechanisms across a parasite's life cycle.•RNA modifications …

Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global
importance. Asexual blood stage replication, via a process called schizogony, is an …

Faithful chromosome segregation of 8 duplicated haploid genomes into 8 daughter gametes
is essential for male gametogenesis and mosquito transmission of Plasmodium …

Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …

Malaria vaccination approaches using live Plasmodium parasites are currently explored,
with either attenuated mosquito-derived sporozoites or attenuated blood-stage parasites …

Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The
protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialized …

Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred
by a complex array of subpellicular microtubules (SPMT) associated with the inner …

Plasmodium falciparum, the causative agent of malaria, poses a significant global health
challenge, yet much of its biology remains elusive. A third of the genes in the P. falciparum …

Genome-wide screening in apicomplexan species has transformed our understanding of
these parasitic protozoa. Kimmel et al. report a'knock sideways' system and provide a …

All the pathology and symptoms associated with malaria are caused by the growth of
Plasmodium parasites inside human red blood cells. This process, which in the case of the …