Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

The primary enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH)
and aldehyde dehydrogenase (ALDH). Both enzymes occur in several forms that are …

Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-
genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, and …

This reprinted article originally appeared in Psychological Bulletin, 2006, Vol 132 (4), 607-
621.(The following abstract of the original article appeared in record 2006-08436-008.) Meta …

BACKGROUND: The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect
predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene …

A large segment of the population suffers from addiction to alcohol, smoking, or illicit drugs.
Not only do substance abuse and addiction pose a threat to health, but the consequences of …

Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …

Individual differences in subjective responses to alcohol consumption represent genetically
mediated biobehavioral mechanisms of alcoholism risk (ie, endophenotype). The objective …

Alcohol dependence (AD) is a multifactorial and polygenic disorder involving complex gene-
to-gene and gene-to-environment interactions. Several genome-wide association studies …

Alcoholism is a complex behavioural disorder. Molecular genetics studies have identified
numerous candidate genes associated with alcoholism. It is crucial to verify the disease …