Metabolic and signaling biochemical pathways have numerous steps that involve the
hydrolytic cleavage of peptide or phosphate ester bonds. Although both types of bonds are …

Numerous studies, both in enzymatic and nonenzymatic catalysis, have been undertaken to
understand the way by which metal ions, especially zinc ions, promote the hydrolysis of …

Abstract Background Soluble inorganic pyrophosphatase (PPase), an essential enzyme
central to phosphorus metabolism, catalyzes the hydrolysis of the phosphoanhydride bond …

Pyrophosphate (PP i) is the smallest member of the polyphosphate family and is formed by
two phosphate (P i) residues linked by a phosphoanhydride bond. A specific enzyme …

Sowohl bei enzymatischen als auch bei nichtenzymatischen Katalysen sind zahlreiche
Untersuchungen durchgeführt worden, um zu verstehen, wie Metallionen–besonders …

Here, we describe high-resolution X-ray structures of Escherichia coli inorganic
pyrophosphatase (E-PPase) complexed with the substrate, magnesium, or manganese …

The three‐dimensional structure of the manganese‐phosphate complex of inorganic
pyrophosphatase from Saccharomyces cerevisiae has been refined to an R factor of 19.0 …

Abstract Comparison and multiple alignments of amino acid sequences of a representative
number of related enzymes demonstrate the existence of certain positions of amino acid …

A sensitive and simple method for real-time detection of inorganic pyrophosphatase
(PPase)(EC 3.6. 1.1) activity has been developed. The method is based on PPase-induced …

Two structures of Escherichia coli soluble inorganic pyrophosphatase (EPPase) complexed
with calcium pyrophosphate (CaPPi-EPPase) and with Ca2+ (Ca2+-EPPase) have been …