Since their first recognition in human cases about four decades ago, rotaviruses have
remained the leading cause of acute severe dehydrating diarrhea among infants and young …

Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant
and childhood morbidity and mortality particularly in developing countries. Nearly every …

Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among
children in developing countries. The host response to enteric viruses occurs primarily within …

Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue).
For over two decades, it has been widely accepted that the 10 segments of the dsRNA …

Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in
young children (< 5years) and animals worldwide. RV primarily infects mature enterocytes in …

Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a
relevant role in controlling viralw infections. Three types of IFNs, type I (IFN-α, IFN-β), II (IFN …

Rotavirus infects intestinal epithelial cells and is the leading cause of gastroenteritis in
infants worldwide. Upon viral infection, intestinal cells produce type I and type III interferons …

The intestinal epithelium can limit enteric pathogens by producing antiviral cytokines, such
as IFNs. Type I IFN (IFN-α/β) and type III IFN (IFN-λ) function at the epithelial level, and their …

Selected topics in the field of rotavirus immunity are reviewed focusing on recent
developments that may improve efficacy and safety of current and future vaccines …

The type I interferon (IFN) system mediates a wide variety of antiviral effects and represents
an important first barrier to virus infection. Consequently, viruses have developed an …