Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

Activation of the cyclic guanosine monophosphate (GMP)-AMP (cGAMP) sensor STING
requires its translocation from the endoplasmic reticulum to the Golgi apparatus and …

Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

The spectrum of all glycan structures—the glycome—is immense. In humans, its size is
orders of magnitude greater than the number of proteins that are encoded by the genome …

In the past years, the research focus on the effects of MP on aquatic organisms extended
from marine systems towards freshwater systems. An important freshwater model organism …

Cohesin regulates sister chromatid cohesion during the mitotic cell cycle with Nipped-B-Like
(NIPBL) facilitating its loading and unloading. In addition to this canonical role, cohesin has …

The zinc finger protein Snail is a master regulator of epithelial–mesenchymal transition
(EMT) and a strong inducer of tumor metastasis, yet the signal cascades triggered by Snail …

Integration of inorganic sulfate into biological molecules plays an important role in biological
systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation …

Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …