Breast cancer is the leading cause of death among solid tumours in women, and its
incidence is increasing in the West. Adjuvant chemotherapy and hormonal treatment …

Background: The latest immunotherapy, used in the treatment of non-small cell lung cancer
(NSCLC), uses monoclonal antibodies directed against programmed death ligand 1 (PD-L1) …

The mammalian brain contains neural stem cells (NSCs) that allow continued neurogenesis
throughout the life of the animal. However, neurogenesis is known to decline during aging …

One of the greatest scientific discoveries of the 20th century is that the mammalian brain can
give rise to new neurons throughout the lifespan. The phenomenon of adult neurogenesis …

Objectives: Expression of the nuclear Ki‐67 protein (pKi‐67) is strongly associated with cell
proliferation. For this reason, antibodies against this protein are widely used as prognostic …

In β-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently
understood. We analyzed mice affected by β-thalassemia and observed, unexpectedly, a …

The cerebellar cortex consists of a small set of neuronal cell types interconnected in a highly
stereotyped way. While the development of cerebellar cortical projection neurons, ie …

Context: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in
women, but its etiology remains obscure. Recent data suggest that an intrinsic abnormality …

Minichromosome maintenance proteins (Mcm) 2–7 play essential roles in eukaryotic DNA
replication. Several reports have indicated the usefulness of Mcm proteins as markers of …

Abstract Minichromosome maintenance (MCM) proteins 2–7 are important in DNA
replication licensing. Functional roles beyond licensing are speculated. In addition …