Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome

DA Dumesic, SE Oberfield, E Stener-Victorin… - Endocrine …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both
adverse reproductive and metabolic implications for affected women. However, there is …

Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models

ASL Caldwell, LJ Middleton, M Jimenez, R Desai… - …, 2014 - academic.oup.com
Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a
range of reproductive, metabolic and endocrine defects including anovulation, infertility …

A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice

AS Kauffman, VG Thackray, GE Ryan… - Biology of …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack
of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat …

The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS)

EA Coutinho, AS Kauffman - Medical Sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting
at least 10% of women of reproductive age. PCOS is typically characterized by the presence …

Role of anti-Müllerian hormone in the pathogenesis of polycystic ovary syndrome

D Dewailly, AL Barbotin, A Dumont… - Frontiers in …, 2020 - frontiersin.org
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has
open major pathophysiological issues. This review addresses the three most important …

Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

S Jahan, A Abid, S Khalid, T Afsar, G Shaheen… - Journal of ovarian …, 2018 - Springer
Background PCOS is a leading endocrinopathy of young women instigating androgens
elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The …

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model

A Benrick, B Chanclón, P Micallef… - Proceedings of the …, 2017 - National Acad Sciences
Adiponectin, together with adipocyte size, is the strongest factor associated with insulin
resistance in women with polycystic ovary syndrome (PCOS). This study investigates the …

Polycystic ovary syndrome and autism: a test of the prenatal sex steroid theory

A Cherskov, A Pohl, C Allison, H Zhang… - Translational …, 2018 - nature.com
Elevated levels of prenatal testosterone may increase the risk for autism spectrum conditions
(autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated …

Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

S Osuka, N Nakanishi, T Murase… - Reproductive …, 2019 - Wiley Online Library
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among
women of reproductive age and a major cause of infertility; however, the pathophysiology of …