Background NTRK gene fusions have been identified in various tumors; some requiring
aggressive therapy and sometimes new TRK inhibitors (TRKi). We aimed to describe a …

In the past decade, several discoveries have documented the existence of innervation in
ovarian cancer and cervical cancer. Notably, various neurotransmitters released by the …

Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-
receptor kinases that have been associated with human cancer development, contributing to …

Nerve growth factor (NGF) is increasingly implicated in cervical cancer progression, but its
mechanism in cervical cancer is unclear. Here, studies demonstrate that NGF inhibits the …

Cervical cancer is primarily caused by the infection of high-risk human papillomavirus
(hrHPV). Moreover, tumor immune microenvironment plays a significant role in the …

Nerve growth factor (NGF), a prototypical neurotrophic factor essential for neuronal cell
proliferation and survival, has been implicated as a marker of tumor progression, as well as …

The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic
target in oncology. In breast cancer, TrkA contributes to metastasis but the …

Simple Summary Sortilin is a protein with tumour-suppressor activity. Among other functions,
sortilin moves around other proteins in the cell and also out of it by leading them to small …

CD74 is a type II cell surface receptor found to be highly expressed in several hematological
and solid cancers, due to its ability to activate pathways associated with tumor cell survival …

Although the role of nerves in stimulating cellular growth and dissemination has long been
described in tissue regeneration studies, until recently a similar trophic role of nerves in …