Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
lead to mitochondrial damage and accelerated aging. The interaction between persistent …
Pathogenicity and virulence of chikungunya virus
W Freppel, LA Silva, KA Stapleford, LJ Herrero - Virulence, 2024 - Taylor & Francis
Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-
severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating …
severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating …
Mayaro virus pathogenesis and immunity in rhesus macaques
WC Weber, CS Labriola, CN Kreklywich… - PLoS neglected …, 2023 - journals.plos.org
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and
persistent arthritogenic disease. While MAYV was previously reported to infect non-human …
persistent arthritogenic disease. While MAYV was previously reported to infect non-human …
Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions
SA Thannickal, L Battini, SN Spector, MG Noval… - Journal of …, 2024 - Am Soc Microbiol
In a previous study to understand how the chikungunya virus (CHIKV) E1 glycoprotein β-
strand c functions, we identified several attenuating variants at E1 residue V80 and the …
strand c functions, we identified several attenuating variants at E1 residue V80 and the …
[HTML][HTML] MLN4924 alleviates autoimmune myocarditis by promoting Act1 degradation and blocking Act1-mediated mRNA stability
Z Jiang, Z Li, Y Chen, N Nie, X Liu, J Liu… - International …, 2024 - Elsevier
Background Prolonged exposure to interleukin-17A (IL-17A) can induce autoimmune
myocarditis, and MLN4924, an inhibitor of NEDD8 activating enzyme (NAE), has been …
myocarditis, and MLN4924, an inhibitor of NEDD8 activating enzyme (NAE), has been …
New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy
W Wang, H Jia, X Hua, J Song - Heart Failure Reviews, 2024 - Springer
Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy
(ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains …
(ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains …
Cracking the code: ET-1 signaling unlocks new therapies for virus-induced osteoarthritis
WH Ng, PCH Tang, S Mahalingam - npj Viruses, 2024 - nature.com
Rheumatic symptoms such as joint inflammation and pain are known features of SARS-CoV-
2 infection, though the mechanisms remain unclear. Au and colleagues identified the …
2 infection, though the mechanisms remain unclear. Au and colleagues identified the …
Differential restriction of chikungunya virus in primary human cardiac endothelial cells occurs at multiple steps in the viral life cycle
SN Spector, MG Noval, KA Stapleford - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Arthropod-borne viruses (arboviruses) constitute a significant ongoing public health threat,
as the mechanisms of pathogenesis remain incompletely understood. Cardiovascular …
as the mechanisms of pathogenesis remain incompletely understood. Cardiovascular …
The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity
SA Thannickal, L Battini, SN Spector, MG Noval… - bioRxiv, 2023 - biorxiv.org
Alphaviruses infect both mammals and insects, yet the distinct mechanisms that
alphaviruses use to infect different hosts are not well defined. In this study, we characterize …
alphaviruses use to infect different hosts are not well defined. In this study, we characterize …