Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Network models to enhance the translational impact of cross-species studies
Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …
understanding specific aspects of the human condition. However, the translation of findings …
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
A key hallmark of Alzheimer's disease (AD) pathology is the intracellular accumulation of tau
protein in the form of neurofibrillary tangles across large-scale networks of the human brain …
protein in the form of neurofibrillary tangles across large-scale networks of the human brain …
The anti-Alzheimer potential of novel spiroindolin-1, 2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents
In this study, a new series of spiro indolin-1, 2-diazepine were designed, synthesized, and
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach …
Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms
AF Khan, Y Iturria-Medina - Translational Psychiatry, 2024 - nature.com
From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …
underlying neurodegenerative disorders remain poorly understood. The clinical view of …
[HTML][HTML] Connectome-based biophysics models of Alzheimer's disease diagnosis and prognosis
With the increasing prevalence of Alzheimer's disease (AD) among aging populations and
the limited therapeutic options available to slow or reverse its progression, the need has …
the limited therapeutic options available to slow or reverse its progression, the need has …
[HTML][HTML] Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease
Neurodegenerative diseases such as Alzheimer's disease (AD) exhibit pathological
changes in the brain that proceed in a stereotyped and regionally specific fashion, but the …
changes in the brain that proceed in a stereotyped and regionally specific fashion, but the …
Directionality bias is necessary to explain spatiotemporal progression of pathology in mouse models of tauopathy
Mounting evidence implicates trans-synaptic connectome-based spread as a shared
mechanism behind different tauopathic conditions, yet also suggests there is divergent …
mechanism behind different tauopathic conditions, yet also suggests there is divergent …
Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome
Brain regions in Alzheimer's (AD) exhibit distinct vulnerability to the disease's hallmark
pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles …
pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles …
Integrating neurotransmitter receptor architecture in whole-brain computational models of neurodegenerative disease progression
A Khan - 2024 - escholarship.mcgill.ca
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the prevailing causes of
dementia and movement disorder, respectively. These neurodegenerative diseases are …
dementia and movement disorder, respectively. These neurodegenerative diseases are …