Superstrong, superstiff, and conductive alginate hydrogels

D Ji, JM Park, MS Oh, TL Nguyen, H Shin… - Nature …, 2022 - nature.com
For the practical use of synthetic hydrogels as artificial biological tissues, flexible electronics,
and conductive membranes, achieving requirements for specific mechanical properties is …

Repair strategies and bioactive functional materials for intervertebral disc

D Wu, G Li, X Zhou, W Zhang, H Liang… - Advanced Functional …, 2022 - Wiley Online Library
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which
represents a highly prevalent chronic aging‐associated disorder with a large socio …

Recent strategies for strengthening and stiffening tough hydrogels

D Ji, J Kim - Advanced NanoBiomed Research, 2021 - Wiley Online Library
Hydrogels are major components of the human body. To replace a damaged hydrogel in the
body or support/monitor its normal operation, artificial hydrogels similar to those found in …

[HTML][HTML] TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair

Q Wei, D Liu, G Chu, Q Yu, Z Liu, J Li, Q Meng… - Bioactive Materials, 2023 - Elsevier
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability.
Endogenous repair strategies combining scaffolds and growth factors show great promise in …

Development of a nanohybrid peptide hydrogel for enhanced intervertebral disc repair and regeneration

BM Conley, L Yang, B Bhujel, J Luo, I Han, KB Lee - Acs Nano, 2023 - ACS Publications
Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …

A perfusable, multifunctional epicardial device improves cardiac function and tissue repair

S Huang, D Lei, Q Yang, Y Yang, C Jiang, H Shi… - Nature medicine, 2021 - nature.com
Despite advances in technologies for cardiac repair after myocardial infarction (MI), new
integrated therapeutic approaches still need to be developed. In this study, we designed a …

Construction of biomimetic artificial intervertebral disc scaffold via 3D printing and electrospinning

M Zhu, J Tan, L Liu, J Tian, L Li, B Luo, C Zhou… - Materials Science and …, 2021 - Elsevier
Intervertebral disc (IVD) degeneration is a clinically disease that seriously endangers
people's health. Tissue engineering provides a promising method to repair and regenerate …

Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative …

Q Yu, F Han, Z Yuan, Z Zhu, C Liu, Z Tu, Q Guo… - Acta Biomaterialia, 2022 - Elsevier
Tissue engineering holds potential in the treatment of intervertebral disc degeneration (IDD).
However, implantation of tissue engineered constructs may cause foreign body reaction and …

Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy

L Yang, C Yu, X Fan, T Zeng, W Yang, J Xia… - Journal of …, 2022 - Springer
Developing smart hydrogels with integrated and suitable properties to treat intervertebral
disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical …

Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy

SR Sloan Jr, C Wipplinger, S Kirnaz… - Science translational …, 2020 - science.org
Tissue-engineered approaches for the treatment of early-stage intervertebral disc
degeneration have shown promise in preclinical studies. However, none of these therapies …