The proteasome has emerged as an important clinically relevant target for the treatment of
hematologic malignancies. Since the Food and Drug Administration approved the first-in …

Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal
carcinogenesis. The pathogenic mechanisms of colorectal cancer (CRC) initiation and …

Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug
resistance and side effects of the current treatment options. The high mortality associated …

Background A number of constitutively activated signaling pathways play critical roles in the
survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT …

Background The F-box protein S-phase kinase-associated protein 2 (Skp2) is
overexpressed and correlated with poor prognosis in human malignancies, including …

Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the
clonal proliferation of lymphoid precursors with arrested maturation. Although …

Background Recent epidemiological studies have suggested that obesity is associated with
ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor …

Abstract Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in
epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important anticarcinogenic …

We provide evidence that thymoquinone (TQ), a natural compound isolated from Nigella
sativa, induces growth inhibition and apoptosis in several primary effusion lymphoma (PEL) …

The ubiquitin–proteasome system is a major pathway for protein degradation. Targeting this
pathway using proteasome inhibitors represents a novel approach for the treatment of …