The involvement of long non-coding RNAs in bone

C Aurilia, S Donati, G Palmini, F Miglietta… - International journal of …, 2021 - mdpi.com
A harmonious balance between osteoblast and osteoclast activity guarantees optimal bone
formation and resorption, pathological conditions affecting the bone may arise. In recent …

Post-transcriptional regulatory crosstalk between MicroRNAs and canonical TGF-β/BMP signalling cascades on osteoblast lineage: a comprehensive review

HY Loh, BP Norman, KS Lai, WH Cheng… - International Journal of …, 2023 - mdpi.com
MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs
about 19 to 22 nucleotides in length, that have been reported to have important roles in the …

Inhibition of exosomal miR‐24‐3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3

Y Xu, L Ouyang, L He, Y Qu, Y Han… - Journal of Cellular and …, 2020 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the common ailments of elderly people suffering from
diabetes. Exosomes containing various active regulators have been found to play a …

[HTML][HTML] Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling

P Cai, Y Lu, Z Yin, X Wang, X Zhou, Z Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
In this study, we used bioinformatics and an in vitro cellular model of glucocorticoid-induced
osteoporosis to investigate mechanisms underlying the beneficial effects of baicalein (BN) …

Prognostic and therapeutic potential of microRNAs for fracture healing processes and non‐union fractures: A systematic review

FL Breulmann, LP Hatt, B Schmitz… - Clinical and …, 2023 - Wiley Online Library
Background Approximately 10% of all bone fractures result in delayed fracture healing or
non‐union; thus, the identification of biomarkers and prognostic factors is of great clinical …

The regulatory role of ferroptosis in bone homeostasis

Y Xiong, L Chen, Z Lin, Y Hu, AC Panayi… - Stem cells …, 2022 - Wiley Online Library
Ferroptosis is an iron‐dependent form of programmed cell death and an important type of
biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can …

[HTML][HTML] YY1-induced DLEU1/miR-149-5p promotes malignant biological behavior of cholangiocarcinoma through upregulating YAP1/TEAD2/SOX2

J Li, X Jiang, Y Xu, P Kang, P Huang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Cholangiocarcinoma is an extremely malignant cancer with poor prognosis. Finding efficient
diagnosis and treatment is the indispensable way to improve the prognosis of CCA patients …

Long noncoding RNAs: recent insights into their role in male infertility and their potential as biomarkers and therapeutic targets

S Zhao, N Heng, B Weldegebriall Sahlu… - International Journal of …, 2021 - mdpi.com
Long noncoding RNAs (lncRNAs) are composed of nucleotides located in the nucleus and
cytoplasm; these are transcribed by RNA polymerase II and are greater than 200 nt in …

Regulation of TGF-β/BMP signaling during osteoblast development by non-coding RNAs: Potential therapeutic applications

I Saranya, N Selvamurugan - Life Sciences, 2024 - Elsevier
Bone is a connective tissue that is metabolically active and serves multiple functions,
including movement, structural support, and organ protection. It is comprised primarily of …

[HTML][HTML] SARS-CoV-2-induced overexpression of miR-4485 suppresses osteogenic differentiation and impairs fracture healing

B Mi, Y Xiong, C Zhang, W Zhou, L Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
The angiotensin-converting enzyme 2 (ACE2) receptor has been identified as the cell entry
point for SARS-CoV-2. Although ACE2 receptors are present in the bone marrow, the effects …