The exposome in atopic dermatitis

N Stefanovic, C Flohr, AD Irvine - Allergy, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between
genetic, immune and external factors. The sum of external factors that an individual is …

Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis

J Meng, Y Li, MJM Fischer, M Steinhoff… - Frontiers in …, 2021 - frontiersin.org
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis

JE Kim, JS Kim, DH Cho, HJ Park - International journal of molecular …, 2016 - mdpi.com
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …

The role of the environment and exposome in atopic dermatitis

N Stefanovic, AD Irvine, C Flohr - Current Treatment Options in Allergy, 2021 - Springer
Purpose of review Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting up
to 20% of children and up to 5% of adults worldwide, contributing to significant disease …

New insights into ILC2 memory

I Martinez‐Gonzalez, F Takei - Immunological Reviews, 2024 - Wiley Online Library
Summary Group 2 Innate Lymphoid Cells (ILC2s) are innate lymphocytes involved in type 2
immunity. ILC2s are abundant at the barrier tissues and upon allergen exposure, respond to …

Diverse role of OX40 on T cells as a therapeutic target for skin diseases

H Iriki, H Takahashi, M Amagai - Journal of Investigative Dermatology, 2023 - Elsevier
OX40 is an important costimulatory molecule for T-cell expansion and survival. Because
OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of …

Role of type 2 innate lymphoid cells in allergic diseases

L Cosmi, F Liotta, L Maggi, F Annunziato - Current Allergy and Asthma …, 2017 - Springer
Abstract Purpose of Review The adaptive immune response orchestrated by type 2 T helper
(Th2) lymphocytes, strictly cooperates with the innate response of group 2 innate lymphoid …

[HTML][HTML] Dendritic cell immunoreceptor drives atopic dermatitis by modulating oxidized CaMKII-involved mast cell activation

X Luo, J Chen, H Yang, X Hu, MP Alphonse, Y Shen… - JCI insight, 2022 - ncbi.nlm.nih.gov
Allergens have been identified as potential triggers in patients with atopic dermatitis (AD).
Patients with AD are highly sensitive to cockroach allergen. The underlying mechanism …

The dawn of a new era in atopic dermatitis treatment

K Yamamura, T Nakahara - Journal of Clinical Medicine, 2022 - mdpi.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, and
the condition is typified by barrier dysfunction and immune dysregulation. Recent studies …

Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s

WS Kong, N Tsuyama, H Inoue, Y Guo, S Mokuda… - Scientific reports, 2021 - nature.com
Breastfeeding influences the immune system development in infants and may even affect
various immunological responses later in life. Breast milk provides a rich source of early …