Development of the thyroid gland

M Nilsson, H Fagman - Development, 2017 - journals.biologists.com
Thyroid hormones are crucial for organismal development and homeostasis. In humans,
untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism …

Prostate organogenesis: tissue induction, hormonal regulation and cell type specification

R Toivanen, MM Shen - Development, 2017 - journals.biologists.com
Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

Medullary thyroid carcinoma beyond surgery: advances, challenges, and perspectives

L Ceolin, MA da Silveira Duval… - Endocrine-related …, 2019 - erc.bioscientifica.com
Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from thyroid C cells
and accounts for 2–4% of all malignant thyroid neoplasms. MTC may occur sporadically or …

Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development

ME Magaletta, M Lobo, EM Kernfeld, H Aliee… - Nature …, 2022 - nature.com
Maldevelopment of the pharyngeal endoderm, an embryonic tissue critical for patterning of
the pharyngeal region and ensuing organogenesis, ultimately contributes to several classes …

Calcitonin: Current concepts and differential diagnosis

A Kiriakopoulos, P Giannakis… - … in endocrinology and …, 2022 - journals.sagepub.com
Calcitonin (CT) is most effectively produced by the parafollicular cells of the thyroid gland. It
acts through the calcitonin receptor (CTR), a seven-transmembrane class II G-protein …

A comprehensive review on MEN2B

F Castinetti, J Moley, L Mulligan… - Endocrine-Related …, 2018 - erc.bioscientifica.com
MEN2B is a very rare autosomal dominant hereditary tumor syndrome associated with
medullary thyroid carcinoma (MTC) in 100% cases, pheochromocytoma in 50% cases and …

ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms: the two-faced Janus

E Giannetta, V Guarnotta, B Altieri… - European Journal of …, 2020 - academic.oup.com
An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is
not pathognomonic. The possibility of false positives or other calcitonin-secreting …

Update on multiple endocrine neoplasia type 2: focus on medullary thyroid carcinoma

F Raue, K Frank-Raue - Journal of the Endocrine Society, 2018 - academic.oup.com
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer
syndrome caused by missense gain-of-function mutations in the RET proto-oncogene on …

Unraveling the complex interplay between transcription factors and signaling molecules in thyroid differentiation and function, from embryos to adults

A López-Márquez, C Carrasco-López… - Frontiers in …, 2021 - frontiersin.org
Thyroid differentiation of progenitor cells occurs during embryonic development and in the
adult thyroid gland, and the molecular bases of these complex and finely regulated …

On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood

SN Perera, L Kerosuo - Stem Cells, 2021 - academic.oup.com
Unique to vertebrates, the neural crest (NC) is an embryonic stem cell population that
contributes to a greatly expanding list of derivatives ranging from neurons and glia of the …