Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria
Y Qiao, Y Xu, X Liu, Y Zheng, B Li, Y Han, Z Li… - Nature …, 2022 - nature.com
Owing to the existence of the outer membrane barrier, most antibacterial agents cannot
penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for …
penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for …
Drug combination and repurposing for cancer therapy: the example of breast cancer
AS Correia, F Gärtner, N Vale - Heliyon, 2021 - cell.com
Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it
affects and kills millions of people worldwide, being the subject of intense study both in its …
affects and kills millions of people worldwide, being the subject of intense study both in its …
[HTML][HTML] Hibiscus-cisplatin combination treatment decreases liver toxicity in rats while increasing toxicity in lung cancer cells via oxidative stress-apoptosis pathway
Cisplatin (CIS) is a broad-spectrum anti-carcinogen that causes cytotoxic effects both in
normal and cancer cells. The purpose of this study was to test whether Hibiscus sabdariffa …
normal and cancer cells. The purpose of this study was to test whether Hibiscus sabdariffa …
Oral co-delivery nanoemulsion of 5-fluorouracil and curcumin for synergistic effects against liver cancer
P Guo, C Pi, S Zhao, S Fu, H Yang… - Expert Opinion on …, 2020 - Taylor & Francis
Background A novel nanoemulsion (CU/FU-LN) was developed as an oral 5-fluorouracil
and curcumin co-delivery system for synergistic efficacy against liver cancer. Methods MTT …
and curcumin co-delivery system for synergistic efficacy against liver cancer. Methods MTT …
Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and enhances the chemotherapeutic activity of widely used DNA damaging …
Although several ATR inhibitors are in development, there are unresolved questions
regarding their differential potency, molecular signatures of patients with cancer for …
regarding their differential potency, molecular signatures of patients with cancer for …
pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities
Co-delivery of multiple drugs with complementary anticancer mechanisms by nano-carriers
offers an effective strategy to treat cancer. The combination of drugs with pro-apoptotic and …
offers an effective strategy to treat cancer. The combination of drugs with pro-apoptotic and …
Cell Type–specific Adaptive Signaling Responses to KRASG12C Inhibition
HS Solanki, EA Welsh, B Fang, V Izumi, L Darville… - Clinical Cancer …, 2021 - AACR
Purpose: Covalent inhibitors of KRASG12C specifically target tumors driven by this form of
mutant KRAS, yet early studies show that bypass signaling drives adaptive resistance …
mutant KRAS, yet early studies show that bypass signaling drives adaptive resistance …
Adapalene and doxorubicin synergistically promote apoptosis of TNBC Cells by hyperactivation of the ERK1/2 pathway through ROS induction
Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies,
including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic …
including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic …
Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941
Although advances in diagnostics and therapeutics have prolonged the survival of triple-
negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of …
negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of …
Transferrin-conjugated PLGA nanoparticles for Co-delivery of temozolomide and bortezomib to glioblastoma cells
MJ Ramalho, ID Torres, JA Loureiro… - ACS Applied Nano …, 2023 - ACS Publications
Glioblastoma (GBM) represents almost half of primary brain tumors, and its standard
treatment with the alkylating agent temozolomide (TMZ) is not curative. Treatment failure is …
treatment with the alkylating agent temozolomide (TMZ) is not curative. Treatment failure is …