Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and …

The regulatory mechanisms governing the parallel alignment of hairs, bristles, and
ommatidia in Drosophila have all served as model systems for studying planar signaling and …

Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and
sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing …

JAK/STAT signaling is essential for a wide range of developmental processes in Drosophila
melanogaster. The mechanism by which the JAK/STAT pathway contributes to these …

Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis
orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell …

The Iroquois (Iro) family of genes are found in nematodes, insects and vertebrates. They
usually occur in one or two genomic clusters of three genes each and encode transcriptional …

The JAK/STAT pathway was originally identified in mammals. Studies of this pathway in the
mouse have revealed that JAK/STAT signaling plays a central role during hematopoeisis …

The characterisation of ligands that activate the JAK/STAT pathway has the potential to
throw light onto a comparatively poorly understood aspect of this important signal …

The Drosophila egg develops through closely coordinated activities of associated germline
and somatic cells. An essential aspect of egg development is the differentiation of the …

Cytokines represent essential mediators of cell–cell communication with particularly
important roles within the immune system. These secreted factors are produced in response …