Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies.
Despite evidence for immune mechanisms in lung fibrosis, immunotherapies have been …

The immune system is receiving increasing attention for interstitial lung diseases, as
knowledge on its role in fibrosis development and response to therapies is expanding …

Fibrosis represents the common end stage of chronic organ injury independent of the initial
insult, destroying tissue architecture and driving organ failure. Here we discover a …

The kidney contains a population of resident macrophages from birth that expands as it
grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages …

Regulation of endosomal Toll-like receptor (TLR) responses by the chemokine CXCL4 is
implicated in inflammatory and fibrotic diseases, with CXCL4 proposed to potentiate TLR …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Aim Patients with systemic sclerosis (SSc) present various clinical and radiological oral
manifestations. However, precise evaluation of the oral features associated with diffuse …

Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective
tissue diseases, specifically characterized by vascular abnormalities and inflammatory and …

Regulation of the profile and magnitude of toll-like receptor (TLR) responses is important for
effective host defense against infections while minimizing inflammatory toxicity. The …

CXCL4 is an important biomarker of systemic sclerosis (SSc), an incurable autoimmune
disease characterized by vasculopathy and skin/internal organs fibrosis. CXCL4 contributes …