Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

Abstract We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-
DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and …

Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS
spectra from screening small molecules in fields such as environmental analysis, drug …

Background Lipids are ubiquitous and serve numerous biological functions; thus lipids have
been shown to have great potential as candidates for elucidating biomarkers and pathway …

The boost of research output in lipidomics during the last decade is tightly linked to improved
instrumentation in mass spectrometry. Associated with this trend is the shift from low …

Lipidomics studies suffer from analytical and annotation challenges because of the great
structural similarity of many of the lipid species. To improve lipid characterization and …

The implication of lipid dysregulation in diseases, toxic exposure outcomes, and
inflammation has brought great interest to lipidomic studies. However, lipids have proven to …

Isaac Newton famously observed that “if I have seen further it is by standing on the
shoulders of giants.” We propose that this sentiment is a powerful motivation for the “open …

Lipids have a wide-range of biological functions enabled by enormous diversity in lipid
structure. Combinations of structural motifs (eg, fatty acids and head group moieties linked to …