Advancing the use of genome-wide association studies for drug repurposing
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …
complex diseases, which are broadly expected to lead to the identification of new drug …
[HTML][HTML] Examining the biological mechanisms of human mental disorders resulting from gene-environment interdependence using novel functional genomic …
PP Silveira, MJ Meaney - Neurobiology of Disease, 2023 - Elsevier
We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …
non-human model systems can improve our understanding of the effect of gene …
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
[HTML][HTML] Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder
Genetically informed drug development and repurposing is an attractive prospect for
improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is …
improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is …
Genetic influences on circulating retinol and its relationship to human health
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes
throughout the human lifespan. Here, we perform the largest genome-wide association …
throughout the human lifespan. Here, we perform the largest genome-wide association …
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness
WR Reay, MP Geaghan, MJ Cairns - Nature communications, 2022 - nature.com
Pneumonia remains one of the leading causes of death worldwide. In this study, we use
genome-wide meta-analysis of lifetime pneumonia diagnosis (N= 391,044) to identify four …
genome-wide meta-analysis of lifetime pneumonia diagnosis (N= 391,044) to identify four …
Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance
Almost half of individuals diagnosed with schizophrenia also present with a substance use
disorder, however, little is known about potential molecular mechanisms underlying this …
disorder, however, little is known about potential molecular mechanisms underlying this …
Multiomic prioritisation of risk genes for anorexia nervosa
BackgroundAnorexia nervosa (AN) is a psychiatric disorder associated with marked
morbidity. Whilst AN genetic studies could identify novel treatment targets, integration of …
morbidity. Whilst AN genetic studies could identify novel treatment targets, integration of …
[HTML][HTML] Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating …
Y Zheng, W Liu, X Zhu, M Xu, B Lin, Y Bai - Redox Biology, 2024 - Elsevier
Background Previous studies have shown that inflammatory and antioxidant dietary patterns
can modify the risk of COPD, yet few studies have examined the association of these diets …
can modify the risk of COPD, yet few studies have examined the association of these diets …
Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension
BACKGROUND: Hypertension is a key risk factor for major adverse cardiovascular events
but remains difficult to treat in many individuals. Dietary interventions are an effective …
but remains difficult to treat in many individuals. Dietary interventions are an effective …