Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms
J Wang, F Wang, J Ke, Z Li, C Xu, Q Yang… - Science Translational …, 2022 - science.org
The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism
Y Wang, J Chen, WQ Gao, R Yang - Cell death discovery, 2022 - nature.com
Abstract N6-methyladenine (m6A) is the most predominant RNA modification, which has
been shown to be related to many types of cancers. However, understanding of its role in …
been shown to be related to many types of cancers. However, understanding of its role in …
PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
R Lakhia, H Ramalingam, CM Chang… - Nature …, 2022 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD), among the most common human
genetic conditions and a frequent etiology of kidney failure, is primarily caused by …
genetic conditions and a frequent etiology of kidney failure, is primarily caused by …
Amino acid metabolism in kidney health and disease
MGE Knol, VC Wulfmeyer, RU Müller… - Nature Reviews …, 2024 - nature.com
Amino acids form peptides and proteins and are therefore considered the main building
blocks of life. The kidney has an important but under-appreciated role in the synthesis …
blocks of life. The kidney has an important but under-appreciated role in the synthesis …
Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61
YP Song, JW Lv, ZC Zhang, QH Qian… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Several epidemiological investigations demonstrated that maternal arsenic
(As) exposure elevated risk of fetal growth restriction (FGR), but the mechanism remains …
(As) exposure elevated risk of fetal growth restriction (FGR), but the mechanism remains …
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2‐dependent mechanism
WJ Ni, H Zhou, H Lu, NN Ma, BB Hou… - Clinical and …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) is of great importance in renal physiology
and disease progression, but its function and mechanism in renal fibrosis remain to be …
and disease progression, but its function and mechanism in renal fibrosis remain to be …