Cutaneous mycobacterial infections

C Franco-Paredes, LA Marcos… - Clinical microbiology …, 2018 - Am Soc Microbiol
Humans encounter mycobacterial species due to their ubiquity in different environmental
niches. In many individuals, pathogenic mycobacterial species may breach our first-line …

The case for modeling human infection in zebrafish

MC Gomes, S Mostowy - Trends in microbiology, 2020 - cell.com
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

PF Ledur, K Karmirian, CSG Pedrosa, LRQ Souza… - Scientific reports, 2020 - nature.com
Zika virus (ZIKV) has been extensively studied since it was linked to congenital
malformations, and recent research has revealed that astrocytes are targets of ZIKV …

Zebrafish infection: from pathogenesis to cell biology

V Torraca, S Mostowy - Trends in cell biology, 2018 - cell.com
The study of host–pathogen interactions has illuminated fundamental research avenues in
both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable …

[HTML][HTML] Treatment and evaluation advances in leprosy neuropathy

GJ Ebenezer, DM Scollard - Neurotherapeutics, 2021 - Elsevier
Neuropathy and related disabilities are the major medical consequences of leprosy, which
remains a global medical concern. Despite major advances in understanding the …

Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

[HTML][HTML] Phenolic glycolipid facilitates mycobacterial escape from microbicidal tissue-resident macrophages

CJ Cambier, SM O'Leary, MP O'Sullivan, J Keane… - Immunity, 2017 - cell.com
Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung
alveoli, where the bacteria first encounter lung-resident alveolar macrophages. We studied …

Pathogenicity and virulence of Mycobacterium leprae

M Sugawara-Mikami, K Tanigawa, A Kawashima… - Virulence, 2022 - Taylor & Francis
Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …

Innate immune responses in leprosy

RO Pinheiro, V Schmitz, BJA Silva, AA Dias… - Frontiers in …, 2018 - frontiersin.org
Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish

G Ferrero, E Gomez, S Lyer, M Rovira… - Journal of leukocyte …, 2020 - academic.oup.com
The mononuclear phagocytic system consists of many cells, in particular macrophages,
scattered throughout the body. However, there is increasing evidence for the heterogeneity …