Importance The initial clinical sign of pubertal onset in girls is breast gland development
(thelarche). Although numerous studies have used recalled age at menarche (first …

Internalizing conditions of psychopathology include depressive and anxiety disorders; they
most often onset in adolescence, are relatively common, and contribute to significant …

Background Child and adolescent mental health problems are common, associated with
wide‐ranging functional impairments, and show substantial continuities into adult life. It is …

Background The timing of puberty in girls is occurring at an increasingly early age. While a
positive family history is recognised as a predisposing factor for early or precocious puberty …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and
cardiovascular disease in women and therefore represents a potential target for early …

This update, written by authors designated by multiple pediatric endocrinology societies
(see List of Participating Societies) from around the globe, concisely addresses topics …

The onset of puberty in adolescents and whether it is related to obesity is an ongoing topic
for debate. Epidemiological cross-sectional and longitudinal studies show a shift towards …

Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …