IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

Anemia is a common complication in chronic kidney disease (CKD), and is associated with a
reduced quality of life, and an increased morbidity and mortality. The mechanisms involved …

Background IL-6 has emerged as a pivotal factor in atherothrombosis. Yet, the safety and
efficacy of IL-6 inhibition among individuals at high atherosclerotic risk but without a …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

Sarcopenia is an aged-related syndrome that is progressive and can be accelerated by
other concomitant disease states. Sarcopenia, characterized by loss of skeletal muscle …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …