Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease
PM Ridker, M Rane - Circulation research, 2021 - Am Heart Assoc
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …
physiological functions traditionally associated with host defense, immune cell regulation …
Anemia in chronic kidney disease: from pathophysiology and current treatments, to future agents
J Portolés, L Martín, JJ Broseta, A Cases - Frontiers in Medicine, 2021 - frontiersin.org
Anemia is a common complication in chronic kidney disease (CKD), and is associated with a
reduced quality of life, and an increased morbidity and mortality. The mechanisms involved …
reduced quality of life, and an increased morbidity and mortality. The mechanisms involved …
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
PM Ridker, M Devalaraja, FMM Baeres… - The Lancet, 2021 - thelancet.com
Background IL-6 has emerged as a pivotal factor in atherothrombosis. Yet, the safety and
efficacy of IL-6 inhibition among individuals at high atherosclerotic risk but without a …
efficacy of IL-6 inhibition among individuals at high atherosclerotic risk but without a …
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …
Osteocyte-related cytokines regulate osteoclast formation and bone resorption
H Kitaura, A Marahleh, F Ohori, T Noguchi… - International journal of …, 2020 - mdpi.com
The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
Inflammation and sarcopenia: a focus on circulating inflammatory cytokines
L Pan, W Xie, X Fu, W Lu, H Jin, J Lai, A Zhang… - Experimental …, 2021 - Elsevier
Sarcopenia is an aged-related syndrome that is progressive and can be accelerated by
other concomitant disease states. Sarcopenia, characterized by loss of skeletal muscle …
other concomitant disease states. Sarcopenia, characterized by loss of skeletal muscle …
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease
T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …
Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome
S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …
disease (CKD), being involved in the development of all‐cause mortality of these patients …
[HTML][HTML] Chronic inflammation in chronic kidney disease progression: role of Nrf2
Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …
and mortality rates in these patients remain high. While pressure-mediated injury is a well …
Distinct longevity mechanisms across and within species and their association with aging
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …