Vaccines for human fungal diseases: close but still a long way to go

LVN Oliveira, R Wang, CA Specht, SM Levitz - npj Vaccines, 2021 - nature.com
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

[HTML][HTML] Fungal vaccines, mechanism of actions and immunology: A comprehensive review

S Nami, R Mohammadi, M Vakili, K Khezripour… - Biomedicine & …, 2019 - Elsevier
Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

Recent advances in our understanding of the environmental, epidemiological, immunological, and clinical dimensions of coccidioidomycosis

C Nguyen, BM Barker, S Hoover, DE Nix… - Clinical microbiology …, 2013 - Am Soc Microbiol
Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides
immitis and C. posadasii. This review is a summary of the recent advances that have been …

Advances in combating fungal diseases: vaccines on the threshold

JE Cutler, GS Deepe Jr, BS Klein - Nature Reviews Microbiology, 2007 - nature.com
The dramatic increase in fungal diseases in recent years can be attributed to the increased
aggressiveness of medical therapy and other human activities. Immunosuppressed patients …

The public health impact of coccidioidomycosis in Arizona and California

RF Hector, GW Rutherford, CA Tsang… - International journal of …, 2011 - mdpi.com
The numbers of reported cases of coccidioidomycosis in Arizona and California have risen
dramatically over the past decade, with a 97.8% and 91.1% increase in incidence rates from …

A review of innate and adaptive immunity to coccidioidomycosis

CY Hung, AP Hsu, SM Holland, J Fierer - Medical mycology, 2019 - academic.oup.com
Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores
produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common …

Coccidioides species: A review of basic research: 2022

TN Kirkland, DA Stevens, CY Hung, S Beyhan… - Journal of Fungi, 2022 - mdpi.com
Coccidioides immitis and posadasii are closely related fungal species that cause
coccidioidomycosis. These dimorphic organisms cause disease in immunocompetent as …

The Rise of Coccidioides: Forces Against the Dust Devil Unleashed

MCC Van Dyke, GR Thompson 3rd… - Frontiers in …, 2019 - frontiersin.org
Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of
Coccidioides posadasii or C. immitis. This neglected disease occurs in the desert areas of …

Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17)

CY Hung, A Gonzalez, M Wüthrich, BS Klein… - Infection and …, 2011 - Am Soc Microbiol
We have previously reported that C57BL/6 mice vaccinated with a live, attenuated mutant of
Coccidioides posadasii, referred to as the ΔT vaccine, are fully protected against pulmonary …

T cell responses to control fungal infection in an immunological memory lens

J Sharma, S Mudalagiriyappa… - Frontiers in …, 2022 - frontiersin.org
In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …