Evidence for a new signaling mechanism consisting of ligand-independent lateral
propagation of receptor activation in the plasma membrane is presented. We visualized the …

The human epidermal growth factor (EGF) receptor (HER) family of receptor tyrosine kinases
has frequently been implicated in cancer. Apart from overexpression or mutation of these …

One of the many functions of skin is to protect the organism against a wide range of
pathogens. Antimicrobial peptides (AMPs) produced by the skin epithelium provide an …

The maintenance of highly proliferative capacity and full differentiation potential is a
necessary step in the initiation of stem cell-based regenerative medicine. Our recent study …

After epithelial disruption by tissue injury, keratinocytes migrate from the wound edge into a
provisional matrix. This process is stimulated by growth factors that signal through epidermal …

Wound healing is a complex, multistep process that can be summarized into three stages,
namely, hemostasis and inflammation, proliferation, and finally, tissue remodeling …

Soluble isoforms of the epidermal growth factor receptor (sEGFR) previously have been
identified in the conditioned culture media (CCM) of the vulvar adenocarcinoma cell line …

Skin toxicity, a common drug-related adverse event observed in cancer patients treated with
epidermal growth factor receptor (EGFR)-directed therapies is rarely seen with therapies …

Induction of heparin-binding epidermal growth factorlike growth factor (HB-EGF) mRNA in
mouse skin organ culture was blocked by two pan-ErbB receptor tyrosine kinase (RTK) …

Ultraviolet (UV) irradiation causes multiple pathologic changes in the skin including
inflammation, immune suppression, photoaging, and cancer. Effects of UV irradiation …