Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …

The human GPCR family comprises circa 800 members, activated by hundreds of thousands
of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily …

Pharmacoresistance of cancer cells to many drugs used in chemotherapy remains a major
challenge for the treatment of cancer. Multidrug resistance transporters, especially ATP …

Host-pathogen interactions play an important role in defining the outcome of a disease.
Recent studies have shown bacterial quorum sensing molecules (QSM) can interact with …

Simple Summary Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-
oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less …

Originally identified on the tongue for their chemosensory role, the receptors for sweet,
umami, and bitter taste are expressed in some cancers where they regulate important …

Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant
treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that …

G protein-coupled receptors (GPCRs) are the largest drug target family. Unfortunately,
applications of GPCRs in cancer therapy are scarce due to very limited knowledge …

Targeting inflammation and the pathways linking inflammation with cancer is an innovative
therapeutic strategy. Tastants are potential candidates for this approach, since taste …